The combination of Line REscan AION confocal system and Kinetix camera offers unparalleled capabilities for live cell imaging. AION with its motorized switchable pinhole, provides spot-on confocality for a wide range of objectives with a large field of view. Kinetix delivers unmatched sensitivity and speed with a quantum efficiency (QE) higher than 95%. This combination is ideal for live cell imaging as it enables high-speed image acquisition of large samples, enhanced by real-time deconvolution and reduced phototoxicity. This adaptable and user friendly system supports simultaneous dual-camera imaging and seamlessly integrates with microscope bodies and software, offering an unprecedented performance in confocal microscopy.