Potara, M., Nagy-Simon, T., Focsan, M., Licarete, E., Soritau, O., Vulpoi, A., & Astilean, S. (2021) | Colloids and Surfaces B: Biointerfaces, 203, 111755
Summary
In this study, the authors developed a nanotherapeutic platform combining near-infrared (NIR) imaging with dual photodynamic (PDT) and photothermal therapy (PTT), while enabling targeted recognition of ovarian cancer cells.
The system was based on IR780 iodide, selected for its NIR fluorescence, singlet oxygen generation, and heat-producing capability. To reduce the hydrophobicity and toxicity of free IR780, the dye was encapsulated in a Pluronic F127-chitosan nanoformulation and functionalized with folic acid for targeted delivery.
The resulting nanocapsules showed temperature-responsive behavior, suitable size for cellular uptake, enhanced fluorescence, and strong stability. Under NIR laser irradiation, they efficiently generated singlet oxygen and produced temperatures up to 46°C. Cell studies using NIH-OVCAR-3 ovarian cancer cells confirmed improved biocompatibility of the encapsulated system. NIR imaging also showed that folic-acid-functionalized nanocapsules could act as intracellular contrast agents while selectively targeting folate receptor-expressing cells.
Compared with free IR780, the targeted nanocapsules achieved stronger laser-induced therapeutic effects. The findings highlight their potential as theranostic agents for image-guided dual PDT-PTT treatment and fluorescence-assisted ovarian cancer surgery.
Read the publication: https://doi.org/10.1016/j.colsurfb.2021.111755