Louisa Mezache, Christophe Leterrier | Microscopy and Microanalysis, 2025, 31, ozaf004
Summary
Super-resolution microscopy has significantly advanced biological research by allowing scientists to investigate cellular structures and dynamic processes with exceptional detail. This review summarizes recent progress in commercially available super-resolution microscope platforms, with a focus on widely adopted technologies including confocal laser scanning microscopy, structured illumination microscopy (SIM), stimulated emission depletion (STED) microscopy, and single-molecule localization microscopy (SMLM).
The authors discuss key technological developments across several modern systems, including Confocal NL GAIA, Nikon NSPARC, CSR Biotech MI-SIM, Zeiss Lattice SIM 5, Leica Microsystems STELLARIS STED, abberior STED and MINFLUX platforms, Abbelight SAFe MN360, and Bruker Vutara VXL SMLM systems. These innovations are designed to deliver higher resolution, lower phototoxicity, improved imaging flexibility across diverse sample types, and a more user-friendly experience. Overall, the review highlights how continued instrument development is expanding access to super-resolution imaging and improving performance for both research and applied microscopy workflows.
Read the publication: https://doi.org/10.1093/mam/ozaf004