In neurobiology, various light microscopy techniques are essential for exploring the complex structures and functions of neurons and neural networks. Confocal microscopy provides high resolution imaging of neuron morphology and synaptic connections in fine detail, especially within brain slices and cultured neurons. Super resolution techniques like STED (stimulated emission depletion) and SMLM (single molecule localization microscopy like STORM, PALM, PAINT, etc) surpass diffraction limits, revealing nanoscale details in synaptic structures and protein localization. These microscopy techniques collectively advance the understanding of neurobiological processes underlying cognition, behaviour, and disease mechanisms.
Neurobiology
Super resolution microscopes that enable deep live cell imaging beyond the diffraction limit using only nanowatts of power.
Capture synaptic connections in fine detail
Limit phototoxicity and photobleaching
Using confocal microscopy in neurobiology poses several challenges, including limited tissue penetration due to light scattering. Photobleaching and phototoxicity can damage delicate neural structures, while resolution limitations make it difficult to capture fine synaptic details. In addition, neuron cell cultures are notoriously difficult to establish and propagate.
Ultra-deep imaging
GAIA enables ultra-deep imaging with minimal light scattering. Due to its minimal phototoxicity provided through Point REscan technology, GAIA enables super resolution imaging of delicate cultured neurons over days.
Products
Discover our solutions
Find the appropriate confocal system for your imaging needs.
NL5+
NL5+ is a fast confocal system with high sensitivity and resolution. Quickly screen a multi-well plate with multicolor images, and select the most promising ones.
AION
AION is the third generation of our fast confocal technology. It provides high contrast images from thicker specimens such as organoids, tissue samples, plant and animal model organisms.
GAIA
The perfect solution for live cell super resolution imaging thanks to its very low phototoxicity.
RCM
Capture datasets with 170nm raw resolution (120nm after deconvolution) by using 60x to 100x high numerical aperture (NA) magnification objectives and keep the laser intensity at a minimum.
KRONOS
KRONOS enables researchers to maximise the output of their REscan confocal system. It unlocks the system’s full potential for an improved imaging experience.
ZEN Module
Operate your AION and NL5+ Line REscan confocal microscopes directly within the familiar ZEISS ZEN environment and bring high speed confocal imaging into the workflow researchers already trust.
NL5
NL5
NL5 is a fast confocal system with high sensitivity and resolution. Quickly screen a multi-well plate with multicolor images, and select the most promising ones.
AION
AION
AION is the third generation of our fast confocal technology. It provides high contrast images from thicker specimens such as organoids, tissue samples, plant and animal model organisms.
GAIA
GAIA
The perfect solution for live cell super resolution imaging thanks to its very low phototoxicity.
RCM
RCM
Capture datasets with 170nm raw resolution (120nm after deconvolution) by using 60x to 100x high numerical aperture (NA) magnification objectives and keep the laser intensity at a minimum.
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