Organoids are three-dimensional, miniature tissue cultures grown from stem cells that replicate the structure and function of real organs, making them essential in biomedical research. They provide an invaluable platform for studying organ development, disease modelling, cancer mechanisms, and drug testing in a way that closely mimics human biology. Unlike traditional cell cultures, organoids contain diverse cell types and exhibit tissue architecture, allowing researchers to observe cellular interactions and responses in a realistic environment. Organoids are also crucial for personalized medicine; patient-derived organoids enable testing treatments tailored to individual genetic profiles, improving therapeutic outcomes. Furthermore, they offer ethical alternatives to animal testing, providing a humane and scalable solution for understanding diseases like cancer, neurological disorders, and infectious diseases.
Organoids
Super resolution microscopes that enable deep live cell imaging beyond the diffraction limit using only nanowatts of power.
Observe cellular interactions in a realistic environment
Increased penetration depth
Using confocal microscopy to image organoids, especially those larger than 120 micrometers, presents challenges due to limited penetration depth, making it difficult to capture internal structures. The high laser intensity required for deeper imaging can cause phototoxicity and photobleaching, damaging cells and reducing image quality. Additionally, extended acquisition times may disrupt dynamic cellular processes.
Deepest and the gentlest conditions
AION and NL5 by Confocal NL provide the deepest and the gentlest conditions among confocal techniques. Due to their high imaging speed (over 50fps) they enable capturing high dynamic cellular processes within organoids over long z stacks.
Discover our solutions
Find the appropriate confocal system for your imaging needs.
NL5
NL5 is a fast confocal system with high sensitivity and resolution. Quickly screen a multi-well plate with multicolor images, and select the most promising ones.
AION
AION is the third generation of our fast confocal technology. It provides high contrast images from thicker specimens such as organoids, tissue samples, plant and animal model organisms.
GAIA
The perfect solution for live cell super resolution imaging thanks to its very low phototoxicity.
RCM
Capture datasets with 170nm raw resolution (120nm after deconvolution) by using 60x to 100x high numerical aperture (NA) magnification objectives and keep the laser intensity at a minimum.
NL5
NL5
NL5 is a fast confocal system with high sensitivity and resolution. Quickly screen a multi-well plate with multicolor images, and select the most promising ones.
AION
AION
AION is the third generation of our fast confocal technology. It provides high contrast images from thicker specimens such as organoids, tissue samples, plant and animal model organisms.
GAIA
GAIA
The perfect solution for live cell super resolution imaging thanks to its very low phototoxicity.
RCM
RCM
Capture datasets with 170nm raw resolution (120nm after deconvolution) by using 60x to 100x high numerical aperture (NA) magnification objectives and keep the laser intensity at a minimum.
