Super resolution (SR) microscopy techniques surpass the diffraction limit, achieving resolutions below 200 nm. These methods utilize advanced strategies like fluorescent molecule localization or selective depletion of excited states to enhance spatial resolution. Super-resolution microscopy is widely applied in cellular and molecular biology to observe subcellular structures, protein interactions, and dynamic processes at a nanoscale level. These techniques have revolutionized our understanding of cellular organization, enabling insights into the molecular mechanisms underlying health and disease.
Deep Live cell imaging in Super Resolution
Super resolution microscopes that enable deep live cell imaging beyond the diffraction limit using only nanowatts of power.
Super resolution
Numerical aperture (NA) and working distance (WD)
The application of SR in deep live cell imaging meets two main obstacles. The first challenge is the trade-off between numerical aperture (NA) and working distance (WD); higher NA improves resolution but limits imaging depth. The second challenge is that the phototoxicity and preparation complexity restrict SR methods like STORM and STED.
Imaging up to 500 microns deep
Confocal NL’s Point REscan GAIA revolutionizes deep SR imaging with objectives featuring longer WDs, enabling imaging up to 500 microns deep. GAIA’s adaptability, reduced phototoxicity, and versatility across samples—from organoids to zebrafish—make it a leading solution for live cell Super resolution imaging in depths previously unachievable.
Products
Discover our solutions
Find the appropriate confocal system for your imaging needs.
NL5
NL5 is a fast confocal system with high sensitivity and resolution. Quickly screen a multi-well plate with multicolor images, and select the most promising ones.
AION
AION is the third generation of our fast confocal technology. It provides high contrast images from thicker specimens such as organoids, tissue samples, plant and animal model organisms.
GAIA
The perfect solution for live cell super resolution imaging thanks to its very low phototoxicity.
RCM
Capture datasets with 170nm raw resolution (120nm after deconvolution) by using 60x to 100x high numerical aperture (NA) magnification objectives and keep the laser intensity at a minimum.
NL5
NL5
NL5 is a fast confocal system with high sensitivity and resolution. Quickly screen a multi-well plate with multicolor images, and select the most promising ones.
AION
AION
AION is the third generation of our fast confocal technology. It provides high contrast images from thicker specimens such as organoids, tissue samples, plant and animal model organisms.
GAIA
GAIA
The perfect solution for live cell super resolution imaging thanks to its very low phototoxicity.
RCM
RCM
Capture datasets with 170nm raw resolution (120nm after deconvolution) by using 60x to 100x high numerical aperture (NA) magnification objectives and keep the laser intensity at a minimum.
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